Purification and characterization of neutrophil chemotactic factors of Streptococcus sanguis |
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Authors: | Yoichiro Miyake Tadashi Yasuhara Kazuhiro Fukui Hidekazu Suginaka Terumi Nakajima Takafumi Moriyama |
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Affiliation: | 1. Department of Microbiology, Hiroshima University School of Dentistry, 1-2-3 Kasumi, Minami-ku, Hiroshima 734, Japan;2. Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10 Kanda Surugadai, Chiyoda-ku, Tokyo 101, Japan |
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Abstract: | Two neutrophil chemotactic factors were isolated from the culture filtrates of Streptococcus sanguis ATCC 10556 and were chemically characterized as N-terminal blocked peptides of low molecular weight. One of the factors consisted of proline, valine, methionine, isoleucine and leucine and the other of methionine, isoleucine, leucine and phenylalanine. In both factors, methionine was detected as the sole N-terminal amino acid, but the amino group was blocked. The removal of N-terminal methionine yielded several N-terminal amino acids, suggesting that S. sanguis produced several N-terminal blocked methionyl peptides, all of which could be chemotactically active. |
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Keywords: | Neutrophil Chemotaxis (S. sanguis) |
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