On the inhibitory power of some further pyrazole derivatives of horse liver alcohol dehydrogenase |
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| Authors: | R Dahlbom B R Tolf A Akeson G Lundquist H Theorell |
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| Affiliation: | Dept. of Organic Chemistry, Faculty of Pharmacy, University of Uppsala Sweden;Nobel Medical Institute, Lab. of Enzyme Research, Karolinska Institute, Stockholm, Sweden |
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| Abstract: | We found in 1969 (1) that the inhibitory power of pyrazole on LADH was greatly increased by methyl substitution in the 4-position. In this paper we have studied the effect of increasing the size of this side chain. The inhbitory power was found to increase by a factor of two for each methyl group added in a normal side chain. Some other side chains were tested. Already the 4-butyl and 4-pentyl pyrazoles were so active that for the calculation of their true inhibition constants these had to be corrected for the concentration of the enzyme (0.0005 μN). To our knowledge this never happened before. |
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