An automated system for genome analysis to support microbial whole-genome shotgun sequencing |
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| Authors: | Sakiyama T Takami H Ogasawara N Kuhara S Kozuki T Doga K Ohyama A Horikoshi K |
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| Affiliation: | Deep-sea Microorganisms Research Group, Japan Marine Science and Technology Center, Yokosuka, Kanagawa. |
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| Abstract: | We developed a semi-automated genome analysis system called GAMBLER in order to support the current whole-genome sequencing project focusing on alkaliphilic Bacillus halodurans C-125. GAMBLER was designed to reduce the human intervention required and to reduce the complications in annotating thousands of ORFs in the microbial genome. GAMBLER automates three major routines: analyzing assembly results provided by genome assembler software, assigning ORFs, and homology searching. GAMBLER is equipped with an interface for convenience of annotation. All processes and options are manipulatable through a WWW browser that enables scientists to share their genome analysis results without choosing computer platforms. |
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