A genome-wide screen for noncoding elements important in primate evolution |
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Authors: | Eliot C Bush Bruce T Lahn |
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Institution: | (1) Department of Human Genetics and Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA;(2) Department of Biology, Harvey Mudd College, Claremont, California, USA |
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Abstract: | Background A major goal in the study of human evolution is to identify key genetic changes which occurred over the course of primate
evolution. According to one school of thought, many such changes are likely to be found in noncoding sequence. An approach
to identifying these involves comparing multiple genomes to identify conserved regions with an accelerated substitution rate
in a particular lineage. Such acceleration could be the result of positive selection. |
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Keywords: | |
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