Rat alpha 1-microglobulin: co-expression in liver with the light chain of inter-alpha-trypsin inhibitor. |
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| Authors: | A Lindqvist T Bratt M Altieri W Kastern B Akerstr?m |
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| Institution: | Department of Medical and Physiological Chemistry, University of Lund, Sweden. |
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| Abstract: | A 1162 bp rat liver cDNA clone encoding the immunoregulatory plasma protein alpha 1-microglobulin was isolated and sequenced. The open reading frame encoded a 349 amino acid polyprotein, including alpha 1-microglobulin, 182 amino acids, and bikunin, the light chain of the plasma protein inter-alpha-trypsin inhibitor, 145 amino acids. The alpha 1-microglobulin/bikunin mRNA was found only in the liver when different tissues were examined. Free alpha 1-microglobulin and a polyprotein, containing both alpha 1-microglobulin and inter-alpha-trypsin inhibitor epitopes, were found in the microsomal fraction from rat liver homogenates. |
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