Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450 |
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| Authors: | A D Rahimtula P J O'Brien |
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| Institution: | 1. Department of Biochemistry, Memorial University of Newfoundland, St. John''s Newfoundland, Canada;2. Department of Biochemistry, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, Texas 75235 USA |
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| Abstract: | Cumene hydroperoxide is capable of supporting the aromatic hydroxylation of a variety of compounds in the presence of hepatic microsomes. NADPH and molecular oxygen are not required. Cytochrome P-450 acts as the catalyst and could not be replaced by other hemoproteins. One mole of hydroperoxide is consumed for every mole of substrate hydroxylated. It is suggested that the oxenoid species of cytochrome P-450 involved in microsomal aromatic hydroxylation is present in a form equivalent to the ferryl from. |
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