Increases of neuropeptide Y-like immunoreactivity in plasma during insulin-induced hypoglycemia in man |
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| Authors: | K Takahashi T Mouri O Murakami K Itoi M Sone M Ohneda M Nozuki K Yoshinaga |
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| Institution: | Second Department of Internal Medicine, Tohoku University School of Medicine, Miyagi, Japan. |
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| Abstract: | Neuropeptide Y-like immunoreactivity (NPY-LI) in plasma during insulin-induced hypoglycemia was measured in 4 healthy male volunteers. Plasma NPY-LI increased from 167 +/- 11 pg/ml to 247 +/- 25 pg/ml 30 min after the administration of insulin (0.1 U/kg body weight IV), reached the maximum (296 +/- 6 pg/ml) 45 min after the insulin, and then decreased. These results suggest that NPY is released into the systemic circulation during insulin-induced hypoglycemia in man. |
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