Losartan attenuates microvascular permeability in mechanical ventilator-induced lung injury in diabetic mice |
| |
Authors: | Chang Chen Zongze Zhang Zijia Li Fan Zhang Mian Peng Yingying Chen Yanlin Wang |
| |
Institution: | 1. Department of Anesthesiology, Zhongnan Hospital, Wuhan University, Donghu Road, Wuhan, 430071, Hubei, People’s Republic of China 2. Department of Anesthesiology, Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China 3. Department of Anesthesiology, Renmin Hospital, Wuhan University, Wuhan, Hubei, People’s Republic of China
|
| |
Abstract: | Mechanical ventilation can cause direct injury to the lungs, a type of injury known as ventilator-induced lung injury (VILI). VILI is associated with up-regulates angiotensinogen and AT1 receptor expression of in the lung. This work explored effects of losartan on VILI in diabetic mice. Ninty-six C57Bl/6 mice were randomly divided into six groups, control group (C group), diabetes group (D group), diabetes mechanical ventilation group (DV group), losartan control group (L + C group), losartan treatment group in diabetic mice (L + D group) and losartan treatment group in mechanical ventilation diabetic mice (L + DV group). Lung W/D, myeloperoxidase (MPO) activity, microvascular permeability, blood–gas analysis, Ang II concentrations and AT-1R protein expression were measured. Compared with D group, DV group increased Ang II concentrations, AT-1R protein expression, W/D ratio, MPO activity, and microvascular permeability. PaO2 were significantly lower in the DV group than D group or control group. Compared with DV group, L + DV group attenuates ventilator-induced lung injury in diabetic mice and prevented the increase Ang II concentrations, AT-1R protein expression and microvascular permeability caused by ventilation in diabetic mice. This study provides in vivo evidence that losartan attenuates microvascular permeability via down-regulates Ang II and AT-1R expression in mechanical ventilator-induced lung injury in diabetic mice. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|