Different responses of DD/He and CC57BR/Mv mice to fasting |
| |
Authors: | Baginskaia N V Vasil'eva E D Il'nitskaia S I Kaledin V I |
| |
Institution: | Institute of Cytology and Genetics, Russian Acad. Sci., Siberian Branch, 10 Pr. Lavrentyeva, Novosibirsk 630090, Russia. |
| |
Abstract: | Reaction to fasting of 2 mice strains differing in their sensitivity to spontaneous and induced hepatocarcinogenesis, has been investigated. It was shown that mice of both strains displayed similar stress reaction after 3-day fasting manifested in increase in blood corticosterone level; and decrease in testosterone level. At the same time, both strains demonstrated opposite changes at tissue- and enzyme levels in the liver. It was shown that DD/He mice, highly sensitive to induction of liver tumors, were characterized by significant increase in tyrosine aminotransferase (TAT) activity and reduction of lipid droplets in hepatocytes. CC57BR/Mv mice, demonstrating high frequency of spontaneous hepatomas and insensitive to induction of such tumors, were characterized by a decrease in the TAT activity and fatty infiltration of the liver. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|