用心率变异功率谱研究出生后心率变慢的机理

目的 :探讨神经机制及心源性因素在出生后心率变慢中的作用。方法 :运用心率变异性的频域和时域分析方法 ,主要为功率谱分析方法 ,以不同年龄组的人和家兔为实验对象 ,对出生后心脏的自主神经调控进行初步探讨 ;并通过观察不同年龄组离体灌流兔心 (无神经体液因素影响 )自律性的变化 ,探讨心脏本身因素是否参与出生后心率变慢的调控。结果 :人和家兔迷走交感对心率的调控作用比在各年龄组之间有显著差异 ,且随年龄增长逐渐升高 ;家兔离体心脏的自主心率在各年龄组之间有显著差异 ,且随年龄增长逐渐降低。结论 :出生后心率减慢与神经机制有关 ,也有心脏本身因素的参与

Studying the mechanism of heart rate slowing down after birth by the method of HRV power spectrum analysis

Aim: To explore the neurological mechanism of heart rate slowing down after birth and to investigate if the heart itself participates in the process. Methods: With the method of HRV power spectrum analysis, the regulatory mechanisms of autonomic nerves over heart rate were studied on different age groups of human beings and rabbits. Similar experiments were carried out on isolated perfused rabbit hearts in order to study if the heart itself were involved in the process of heart rate slowing down as they grew up. Results: The ratio of parasympathetic tone to sympathetic one is significantly increased as a child or rabbit grows up while the heart rate becomes slower. The spontaneous beating of isolated rabbit heart also slows down as the rabbit becomes older. Conclusion: Both of the nerve factor and heart itself are involved in the process of slowing down of heart rate as a child grows up.