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p53 Loss in Breast Cancer Leads to Myc Activation,Increased Cell Plasticity,and Expression of a Mitotic Signature with Prognostic Value
Authors:Angela Santoro  Thalia Vlachou  Lucilla Luzi  Giorgio Melloni  Luca Mazzarella  Errico D’Elia  Xieraili Aobuli  Cristina Elisabetta Pasi  Linsey Reavie  Paola Bonetti  Simona Punzi  Lucia Casoli  Arianna Sabò  Maria Cristina Moroni  Gaetano Ivan Dellino  Bruno Amati  Francesco Nicassio  Luisa Lanfrancone  Pier Giuseppe Pelicci
Affiliation:1. IEO, European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy;2. Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milan, Italy;3. Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA;4. BioPharma Excellence, Agnes-Pockels-Bogen 1, 80922 Munich, Germany;5. Department of Oncology and Hemato-Oncology, University of Milan, Via Santa Sofia 9, 20142 Milan, Italy
Abstract:
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  • Keywords:p53  Myc  CSCs  mammary gland  SC self-renewal  cancer maintenance  reprogramming
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