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Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1
Authors:Luis M Polo  Yingqi Xu  Peter Hornyak  Fernando Garces  Zhihong Zeng  Richard Hailstone  Steve J Matthews  Keith W Caldecott  Antony W Oliver  Laurence H Pearl
Institution:1. Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK;2. Cross-Faculty NMR Centre, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK;3. Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK;4. Division of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW1E 6BT, UK
Abstract:
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  • Keywords:DNA repair  gap repair  poly(ADP-ribose)  PARP  polymorphism  DNA binding
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