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Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection
Authors:Anna Z Wec  Zachary A Bornholdt  Shihua He  Andrew S Herbert  Eileen Goodwin  Ariel S Wirchnianski  Bronwyn M Gunn  Zirui Zhang  Wenjun Zhu  Guodong Liu  Dafna M Abelson  Crystal L Moyer  Rohit K Jangra  Rebekah M James  Russell R Bakken  Natasha Bohorova  Ognian Bohorov  Do H Kim  Kartik Chandran
Institution:1. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA;2. Mapp Biopharmaceutical, San Diego, CA 92121, USA;3. Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada;4. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA;5. Adimab, LLC, Lebanon, NH 03766, USA;6. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA;7. Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada;8. One Health Institute and Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA;9. Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Abstract:
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  • Keywords:Ebola virus  ebolavirus  filovirus  Ebola glycoprotein  human monoclonal antibodies  broadly neutralizing antibodies  antibody engineering  immunotherapy  antiviral drug  antibody cocktail
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