Immunity to the protozoan parasite Eimeria nieschulzi in inbred CD-F rats |
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| Authors: | EM Liburd WD Armstrong JL Mahrt |
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| Institution: | Transplantation Unit, University of Alberta, Edmonton, Alberta, Canada;Department of Pathology and Transplantation Unit, University of Alberta, Edmonton, Alberta, Canada;Department of Zoology, University of Alberta, Edmonton, Alberta, Canada |
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| Abstract: | Immunity to the coccidial parasite, Eimeria nieschulzi, in CD-F rats was assessed by the numbers of oocysts shed in relation to the time after inoculation. Intravenous injections of syngeneic thoracic duct lymphocytes (TDL) from immunized rats elicited various degrees of adoptive immunity against primary infections of E. nieschulzi. Of the 16 rats injected with 109 sensitized TDL, 7 were totally immune to a subsequent challenge by the parasite. This number of injected TDL also raised the serum antibody level to that of immune rats. Contact with immune TDL was deleterious to sporozoites of E. nieschulzi in vitro and produced immunocytoadherence of parasite to cell. |
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