Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts |
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| Authors: | Sandeep K Agarwal Minghua Wu Christopher K Livingston Donald H Parks Maureen D Mayes Frank C Arnett Filemon K Tan |
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| Affiliation: | (1) Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 6431 Fannin Avenue, Houston, TX 77030, USA;(2) Division of Plastic and Reconstructive Surgery, Department of Surgery, The University of Texas Health Science Center at Houston, 6431 Fannin Avenue, Houston, TX 77030, USA |
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| Abstract: | Introduction Increased levels of genes in the type I interferon (IFN) pathway have been observed in patients with systemic sclerosis (SSc), or scleroderma. How type I IFN regulates the dermal fibroblast and its participation in the development of dermal fibrosis is not known. We hypothesized that one mechanism by which type I IFN may contribute to dermal fibrosis is through upregulation of specific Toll-like receptors (TLRs) on dermal fibroblasts. Therefore, we investigated the regulation of TLR expression on dermal fibroblasts by IFN. |
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