An ancient family of SelB elongation factor-like proteins with a broad but disjunct distribution across archaea |
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Authors: | Gemma C Atkinson Vasili Hauryliuk and Tanel Tenson |
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Institution: | (1) Institute of Technology, University of Tartu, Tartu, Estonia |
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Abstract: | Background SelB is the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome. In archaea, only a subset of
methanogens utilizes selenocysteine and encodes archaeal SelB (aSelB). A SelB-like (aSelBL) homolog has previously been identified
in an archaeon that does not encode selenosysteine, and has been proposed to be a pyrrolysyl-tRNA-specific elongation factor
(EF-Pyl). However, elongation factor EF-Tu is capable of binding archaeal Pyl-tRNA in bacteria, suggesting the archaeal ortholog
EF1A may also be capable of delivering Pyl-tRNA to the ribosome without the need of a specialized factor. |
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