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Fertilization in C. elegans requires an intact C-terminal RING finger in sperm protein SPE-42 |
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| Authors: | Luke D Wilson Jacqueline M Sackett Bryce D Mieczkowski Abigail L Richie Kara Thoemke Jon N Rumbley and Tim L Kroft |
| Institution: | (1) Department of Biology, Swenson College of Science and Engineering, University of Minnesota Duluth, 55812 Duluth, MN, USA;(2) Department of Biology, College of St. Scholastica, 55811 Duluth, MN, USA;(3) Department of Pharmacy Practice and Pharmaceutical Sciences, College of Pharmacy, University of Minnesota Duluth, 55812 Duluth, MN, USA |
| Abstract: | BackgroundThe C. elegans sperm protein SPE-42, a membrane protein of unknown structure and molecular function, is required for fertilization. Sperm from worms with spe-42 mutations appear normal but are unable to fertilize eggs. Sequence analysis revealed the presence of 8 conserved cysteine residues in the C-terminal cytoplasmic domain of this protein suggesting these residues form a zinc-coordinating RING finger structure. |
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