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Contribution of SecDF to <Emphasis Type="Italic">Staphylococcus aureus</Emphasis>resistance and expression of virulence factors |
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| Authors: | Chantal Quiblier Annelies S Zinkernagel Reto A Schuepbach Brigitte Berger-Bächi Maria M Senn |
| Institution: | (1) Institute of Medical Microbiology, University of Zurich, Gloriastr. 32, 8006 Zurich, Switzerland;(2) Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Raemistr. 100, 8091 Zurich, Switzerland;(3) Surgical Intensive Care, University Hospital Zurich, University of Zurich, Raemistr. 100, 8091 Zurich, Switzerland |
| Abstract: | BackgroundSecDF is an accessory factor of the conserved Sec protein translocation machinery and belongs to the resistance-nodulation-cell division (RND) family of multidrug exporters. SecDF has been shown in Escherichia coli and Bacillus subtilis to be involved in the export of proteins. RND proteins can mediate resistance against various substances and might be of relevance in antimicrobial therapy. The role of RND proteins in Staphylococcus aureus has not yet been determined. |
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