1,000 structures and more from the MCSG |
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| Authors: | David Lee Tjaart AP de Beer Roman A Laskowski Janet M Thornton Christine A Orengo |
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| Affiliation: | (1) Department of Structural and Molecular Biology, University College London, Darwin Building, Gower Street, WC1E 6BT London, UK;(2) European Bioinformatics Institute, Wellcome Trust Genome Campus, CB10 1SD Hinxton, Cambridge, UK |
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| Abstract: | Background The Midwest Center for Structural Genomics (MCSG) is one of the large-scale centres of the Protein Structure Initiative (PSI). During the first two phases of the PSI the MCSG has solved over a thousand protein structures. A criticism of structural genomics is that target selection strategies mean that some structures are solved without having a known function and thus are of little biomedical significance. Structures of unknown function have stimulated the development of methods for function prediction from structure. |
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