Anti-class a scavenger receptor autoantibodies from systemic lupus erythematosus patients impair phagocytic clearance of apoptotic cells by macrophages <Emphasis Type="Italic">in vitro</Emphasis> |
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Authors: | Xiao-wei Chen Yan Shen Chuan-yin Sun Feng-xia Wu Yi Chen Cheng-de Yang |
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Institution: | (1) Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 145 Shan Dong Middle Road, Shanghai, 200001, PR China;(2) Department of Rheumatology, the first affiliated hospital of Wenzhou Medical College, 2 Fu Xue Alley, Zhejiang, 325000, PR China |
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Abstract: | Introduction Inadequate clearance of apoptotic cells by macrophages is one of the reasons for the breakdown of self-tolerance. Class A
scavenger receptors, macrophage receptor with collagenous structure (MARCO) and scavenger receptor A (SR-A), which are expressed
on macrophages, play important roles in the uptake of apoptotic cells. A previous study reported the presence of the anti-MARCO
antibody in lupus-prone mice and systemic lupus erythematosus (SLE) patients. The purpose of this study was to investigate
the prevalence of anti-class A scavenger receptor antibodies in patients with various autoimmune diseases, in particular SLE,
and the functional implication of those autoantibodies in the phagocytic clearance of apoptotic cells by macrophages. |
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