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Anti-class a scavenger receptor autoantibodies from systemic lupus erythematosus patients impair phagocytic clearance of apoptotic cells by macrophages <Emphasis Type="Italic">in vitro</Emphasis>
Authors:Xiao-wei Chen  Yan Shen  Chuan-yin Sun  Feng-xia Wu  Yi Chen  Cheng-de Yang
Institution:(1) Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 145 Shan Dong Middle Road, Shanghai, 200001, PR China;(2) Department of Rheumatology, the first affiliated hospital of Wenzhou Medical College, 2 Fu Xue Alley, Zhejiang, 325000, PR China
Abstract:

Introduction  

Inadequate clearance of apoptotic cells by macrophages is one of the reasons for the breakdown of self-tolerance. Class A scavenger receptors, macrophage receptor with collagenous structure (MARCO) and scavenger receptor A (SR-A), which are expressed on macrophages, play important roles in the uptake of apoptotic cells. A previous study reported the presence of the anti-MARCO antibody in lupus-prone mice and systemic lupus erythematosus (SLE) patients. The purpose of this study was to investigate the prevalence of anti-class A scavenger receptor antibodies in patients with various autoimmune diseases, in particular SLE, and the functional implication of those autoantibodies in the phagocytic clearance of apoptotic cells by macrophages.
Keywords:
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