Effect of cyclosporine A and oligomycin on non-specific permeability of the inner mitochondrial membrane |
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| Authors: | Sergey A Novgorodov Tatjana I Gudz Yulia E Kushnareva Dmitry B Zorov Yury B Kudrjashov |
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| Institution: | A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Department of Biophysics, M.V. Lomonosov Moscow State University, USSR. |
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| Abstract: | The effect of oligomycin and cyclosporine A on the induction of non-specific permeability of the inner mitochondrial membrane by Ca2+ was under study. Both oligomycin and cyclosporine A were able to prevent the activation of non-specific permeability, but cyclosporine A was the only agent which could restore initial permeability of the inner mitochondrial membrane. The effect of cyclosporine A was shown not to be mediated through redistribution of Ca2+ between different mitochondrial subpopulations |
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| Keywords: | Mitochondria Non-specific permeability Cyclosporine A |
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