Low insulin‐like growth factor‐1 level predicts survival in humans with exceptional longevity |
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Authors: | Sofiya Milman Gil Atzmon Derek M. Huffman Junxiang Wan Jill P. Crandall Pinchas Cohen Nir Barzilai |
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Affiliation: | 1. Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, , Bronx, NY, USA;2. Institute for AgingResearch, Albert Einstein College of Medicine, , Bronx, NY, USA;3. Department of Genetics, Albert Einstein College of Medicine, , Bronx, NY, USA;4. Department of Molecular Pharmacology, Albert Einstein College of Medicine, , Bronx, NY, 10461 USA;5. Davis School of Gerontology, University of Southern California, , Los Angeles, CA, 90089 USA |
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Abstract: | Attenuated growth hormone and insulin-like growth factor-1 (GH/IGF-1) signaling is associated with extended lifespan in several animal models. However, the effect of diminished GH/IGF-1 activity on survival in humans has not been confirmed. We tested the hypothesis that IGF-1 levels in nonagenarians (n = 184), measured at study enrollment, predict the duration of their incremental survival. In the Kaplan–Meier analysis, females with IGF-1 levels below the median (≤ 96 ng mL−1) had significantly longer survival compared with females with levels above the median, P < 0.01. However, this survival advantage was not observed in males (P = 0.83). On the other hand, in both males and females with a history of cancer, lower IGF-1 levels predicted longer survival (P < 0.01). IGF-1 level remained a significant predictor of survival duration in linear regression models after multivariable adjustment in females (P = 0.01) and individuals with a history of cancer (P < 0.01). We show for the first time that low IGF-1 levels predict life expectancy in exceptionally long-lived individuals. |
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Keywords: | IGF‐1 insulin‐like growth factor 1 mortality longevity human cancer |
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