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Understanding epigenetic changes in aging stem cells – a computational model approach
Authors:Jens Przybilla  Thimo Rohlf  Markus Loeffler  Joerg Galle
Affiliation:1. Interdisciplinary Center for Bioinformatics, University Leipzig, , 04107 Leipzig, Germany;2. Max‐Planck‐Institute for Mathematics in the Sciences, , 04103 Leipzig, Germany;3. Institute for Medical Informatics, Statistics and Epidemiology, University Leipzig, , 04107 Leipzig, Germany
Abstract:
Keywords:aging of stem cells  clonal competition  DNA methylation  histone modification  mathematical model  population dynamics
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