miR-25 promotes gastric cancer cells growth and motility by targeting RECK |
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Authors: | Hongying Zhao Yu Wang Liu Yang Rongke Jiang Wenqing Li |
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Institution: | 1. Department of Oncology, 5th Affiliated Hospital of Qiqihar Medical College, Daqing LongNan Hospital, Daqing, 163453, China
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Abstract: | Gastric cancer (GC) is the second leading cause of cancer-related death worldwide. Recently, accumulating evidence suggests that microRNAs (miRNAs) play prominent roles in tumorigenesis and metastasis. Here, we confirmed that miR-25 was significantly increased in human GC tissues and cell lines. Forced expression of miR-25 remarkably enhanced cell proliferation, migration, and invasion in GC cells, whereas inhibition of miR-25 by inhibitor caused significant suppression of proliferation and significant increase of apoptosis. Moreover, inhibition of miR-25 significantly decreased migration and invasion of GC cells. Finally, reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was found to be a target of miR-25. Overexpression of RECK could significantly reverse the oncogenic effect of miR-25. Taken together, miR-25 might promote GC cells growth and motility partially by targeting RECK. |
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