Checkpoint effects and telomere amplification during DNA re-replication in fission yeast |
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| Authors: | Katie L Mickle Anna Oliva Joel A Huberman Janet Leatherwood |
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| Affiliation: | (1) Department of Microbiology and Molecular Genetics, SUNY at Stony Brook, Stony Brook, New York, 11794-5222, USA;(2) Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, New York, 14263-0001, USA |
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| Abstract: | Background Although much is known about molecular mechanisms that prevent re-initiation of DNA replication on newly replicated DNA during a single cell cycle, knowledge is sparse regarding the regions that are most susceptible to re-replication when those mechanisms are bypassed and regarding the extents to which checkpoint pathways modulate re-replication. We used microarrays to learn more about these issues in wild-type and checkpoint-mutant cells of the fission yeast, Schizosaccharomyces pombe. |
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