Involvement of an essential gene, mviN, in murein synthesis in Escherichia coli |
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| Authors: | Inoue Azusa Murata Yoshimitsu Takahashi Hiroshi Tsuji Naoko Fujisaki Shingo Kato Jun-ichi |
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| Institution: | Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo 192-0397, Japan. |
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| Abstract: | We isolated a temperature-sensitive mutant with a mutation in mviN, an essential gene in Escherichia coli. At the nonpermissive temperature, mviN mutant cells swelled and burst. An intermediate in murein synthesis, polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine, accumulated in mutant cells. These results indicated that MviN is involved in murein synthesis. |
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