基于蛋白质组学的糖尿病相关生物标记物发现

近年来,随着生活水平的提高和生活方式的转变,我国糖尿病的发病率呈快速上升趋势。然而,目前对糖尿病的发生发展机制仍缺乏系统了解。最近本课题组结合多种蛋白质组学技术对糖尿病的发生发展过程进行研究,发现在大鼠2型糖尿病的发生发展过程中,肝脏线粒体的多个代谢通路蛋白质表达及其修饰发生改变。在人群研究中发现,单氨基酸多态性与肥胖以及糖尿病的发展密切相关。此外,还发现了一些潜在糖尿病相关生物标志物,如载脂蛋白C-I、Ficolin-3等。这些研究有助于完善对糖尿病发病机制的认识,同时也为防治糖尿病提供新的思路与方向。

Discovery of diabetes-associated biomarkers based on proteomic research

In recent years, the alteration of lifestyle renders the rapidly increasing incidence of diabetes in China. However, the pathogenesis of diabetes is lack of systemic understanding. We applied proteomics technologies to indepth study of diabetes pathogenesis. The incidence and development of type 2 diabetes affect protein expression and modifications in various metabolic pathways of liver mitochondrion in rat model. We found that single amino- acid polymorphisms closely associated with the development of obesity and diabetes. In addition, some potential biomarkers including Apolipoprotein C-I and Ficolin-3 were uncovered by proteomic approaches. These studies deepened the understanding of the pathogenesis of diabetes, then provided new clues for the prevention and cure of diabetes.