Th17/Treg细胞失衡与子宫颈癌

Th17细胞是近年发现的一种新型CD4^＋效应性T细胞,以其特异性的分泌IL-17而命名。介导免疫耐受的Treg细胞和介导炎症反应的Th17细胞间功能和分化过程相互对抗,在正常状态下,两者保持平衡,但机体发生功能异常时常表现出Treg/Th17失衡,引起炎性反应、自身免疫性疾病、移植物抗宿主病等的发生和发展,并决定疾病的转归和预后,在肿瘤免疫中亦发挥了重要作用。该文就Treg/Th17失衡在肿瘤,尤其是子宫颈癌发生发展中的作用进行综述。

The imbalance of Th17/Treg cell and cervical cancer

Th17 cells was discovered in recent years as a new type of CD4^＋ effect T cell,which is named after the specific secretion of IL-17.The Treg cells mediate immune tolerance,while the Th17 cells mediate inflammatory response.They are against each other in their functions and differentiation processes.They keep balance in the normal way.While the functional abnormalities occur in our body,they will be imbalanced,then causes inflammation,autoimmune diseases,graft versus host disease,etc.They also play an important role in tumor immunity.This article focuses on the Treg /Th17 imbalance in tumor and especially in the development of uterine cervical carcinoma.