| 胰腺星状细胞活化相关的信号转导通路 |
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| 引用本文： | 陈碧君,孙子林,李凤飞,杨家悦,李玲. 胰腺星状细胞活化相关的信号转导通路[J]. 生命科学, 2012, 0(6): 583-587 |
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| 作者姓名： | 陈碧君 孙子林 李凤飞 杨家悦 李玲 |
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| 作者单位： | 东南大学附属中大医院内分泌科东南大学糖尿病研究所,南京210009 |
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| 基金项目： | 国家自然科学基金项目（30900696,30971399,81170716）;江苏省自然科学基金项目（BK2009278） |
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| 摘 要： | 胰腺纤维化是慢性胰腺炎（chronic pancreatitis,CP）和胰腺癌主要的病理学特征,活化的胰腺星状细胞（pancreatic stellate cells,PSCs）是公认的致胰腺纤维化的主要效应细胞。PSCs的活化涉及到几个重要的信号转导通路：有丝分裂原活化蛋白激酶（mitogen-activated protein kinases,MAPK）、磷酯酰肌醇3激酶（phosphatidylinositol 3-kinase,PI3K）=、Smad信号转导蛋白、过氧化物酶体增生物激活受体-γ（PPAR-γ）、Rho-ROCK等细胞内信号途径。探讨这些信号通路在胰腺纤维化中所起的作用对慢性胰腺炎、胰腺癌及糖尿病的治疗有重要意义。现就与PSCs激活有关的信号通路的研究结合最新进展作一综述。
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| 关 键 词： | 胰腺星状细胞 信号转导 胰腺纤维化 |
The signaling pathways in pancreatic stellate cells |
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| CHEN Bi-Jun,SUN Zi-Lin,LI Feng-Fei,YANG Jia-Yue,LI Ling. The signaling pathways in pancreatic stellate cells[J]. Chinese Bulletin of Life Sciences, 2012, 0(6): 583-587 |
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| Authors: | CHEN Bi-Jun SUN Zi-Lin LI Feng-Fei YANG Jia-Yue LI Ling |
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| Affiliation: | ＊(Department of Endocrinology,Zhongda Hospital,Institute of Diabetes,Southeast University,Nanjing 210009,China) |
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| Abstract: | Pancreatic fibrosis is one of the dominant pathological characters of chronic pancreatitis and pancreatic cancer.Activated pancreatic stellate cells（PSCs） play a pivotal role in pancreatic fibrosis.The activation of PSCs is regulated by several signaling transduction pathways： mitogen-activated protein kinases（MAPK）,phosphatidylinositol 3-kinase（PI3K）,Smad signaling transduction protein,peroxisome proliferator-activated receptor（PPAR）,Rho-ROCK.Identification of signaling molecules that play a crucial role in PSCs activation is important for the development of anti-fibrotic therapies.This review aims at summarizing the signaling transduction pathways that associated with the activation of PSCs and highlighting the recent advancements. |
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| Keywords: | pancreatic stellate cells signaling transduction pancreatic fibrosis |
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