Characterization of the biotin uptake system encoded by the biotin-inducible <Emphasis Type="Italic">bioYMN</Emphasis> operon of <Emphasis Type="Italic">Corynebacterium glutamicum</Emphasis> |
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| Authors: | Jens Schneider Petra Peters-Wendisch K Corinna Stansen Susanne Götker Stanislav Maximow Reinhard Krämer Volker F Wendisch |
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| Institution: | (1) Genetics of Prokaryotes, Faculty of Biology and CeBiTec, Bielefeld University, Bielefeld, Germany;(2) Institute for Biochemistry, Cologne University, Cologne, Germany;(3) Genetics of Prokaryotes, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany |
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| Abstract: | Background The amino acid-producing Gram-positive Corynebacterium glutamicum is auxotrophic for biotin although biotin ring assembly starting from the precursor pimeloyl-CoA is still functional. It
possesses AccBC, the α-subunit of the acyl-carboxylases involved in fatty acid and mycolic acid synthesis, and pyruvate carboxylase
as the only biotin-containing proteins. Comparative genome analyses suggested that the putative transport system BioYMN encoded
by cg2147, cg2148 and cg2149 might be involved in biotin uptake by C. glutamicum. |
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