Frequency-dependent electrodeformation of giant phospholipid vesicles in AC electric field |
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Authors: | Primo? Peterlin |
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Institution: | (1) Faculty of Medicine, Institute of Biophysics, University of Ljubljana, Lipičeva 2, 1000 Ljubljana, Slovenia |
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Abstract: | A model of vesicle electrodeformation is described which obtains a parametrized vesicle shape by minimizing the sum of the
membrane bending energy and the energy due to the electric field. Both the vesicle membrane and the aqueous media inside and
outside the vesicle are treated as leaky dielectrics, and the vesicle itself is modeled as a nearly spherical shape enclosed
within a thin membrane. It is demonstrated (a) that the model achieves a good quantitative agreement with the experimentally
determined prolate-to-oblate transition frequencies in the kilohertz range and (b) that the model can explain a phase diagram
of shapes of giant phospholipid vesicles with respect to two parameters: the frequency of the applied alternating current
electric field and the ratio of the electrical conductivities of the aqueous media inside and outside the vesicle, explored
in a recent paper (S. Aranda et al., Biophys J 95:L19–L21, 2008). A possible use of the frequency-dependent shape transitions of phospholipid vesicles in conductometry of microliter samples
is discussed. |
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Keywords: | Electrodeformation Giant phospholipid vesicle Leaky dielectric Membrane bending energy Vesicle shape |
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