Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression |
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| Authors: | Marie-Solange Mutabaruka Mohamed Aoulad Aissa Aline Delalandre Martin Lavigne Daniel Lajeunesse |
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| Affiliation: | 1.Unité de recherche en Arthose, Centre de recherche du Centre Hospitalier de l''Université de Montréal (CR-CHUM), Hôpital Notre-Dame, 1560 rue Sherbrooke Est, Montréal, QC H2L 4 M1, Canada;2.Chirurgie Orthopédique, Hôpital Maisonneuve-Rosemont, 5415 boul. l''Assomption, Montréal, QC H1T 2 M4, Canada |
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| Abstract: | Introduction Leptin is a peptide hormone with a role in bone metabolism and rheumatic diseases. The subchondral bone tissue plays a prominent role in the pathophysiology of osteoarthritis (OA), related to abnormal osteoblast (Ob) differentiation. Although leptin promotes the differentiation of Ob under normal conditions, a role for leptin in OA Ob has not been demonstrated. Here we determined if endogenous leptin produced by OA Ob could be responsible for the expression of the abnormal phenotypic biomarkers observed in OA Ob. |
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