Production of granulocyte colony-stimulating factor by head and neck carcinomas |
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| Authors: | Mamoru Tsukuda Taro Nagahara Tadayuki Yago Hideki Matsuda Shunsuke Yanoma |
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| Affiliation: | (1) Department of Otorhinolaryngology, Yokohama City University, School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236 Kanagawa, Japan;(2) Department of Biochemistry, Kanagawa Cancer Center, Nakao-cho 54-6, Asahi-ku, Yokohama, 241 Kanagawa, Japan |
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| Abstract: | Detectable levels of G-CSF by enzyme-linked immunosorbent assay (ELISA) were found in sera of 4 out of 15 patients with head and neck carcinomas. Also cells prepared from the tumors of these 4 patients secreted G-CSF. The supernatants of cells derived from all 15 patients did not contain granulocyte-monocyte CSF, monocyte CSF, tumor necrosis factor- , transforming growth factor- 1, epidermal growth factor, interleukin (IL)-1 and IL-6. These findings suggest that leukocytosis in patients with carcinomas might be due to the production of G-CSF by tumor cells.Abbreviations CSF colony stimulating factor - EGF epidermal growth factor - ELISA Enzyme-linked immunosorbent assay - G granulocyte - GM granulocyte-monocyte - IL interluekin - M monocyte - TGF transforming growth factor - TNF tumor necrosis factor |
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| Keywords: | G-CSF production head and neck carcinomas |
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