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A method for aligning RNA secondary structures and its application to RNA motif detection |
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| Authors: | Jianghui?Liu Jason?TL?Wang Jun?Hu |
| Institution: | (1) Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA;(2) Department of Computer Science, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA |
| Abstract: | BackgroundAlignment of RNA secondary structures is important in studying functional RNA motifs. In recent years, much progress has been made in RNA motif finding and structure alignment. However, existing tools either require a large number of prealigned structures or suffer from high time complexities. This makes it difficult for the tools to process RNAs whose prealigned structures are unavailable or process very large RNA structure databases. |
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