The protease-associated domain: a homology domain associated with multiple classes of proteases |
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Authors: | Luo X Hofmann K |
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Affiliation: | 1. Departamento de Física de la Materia Condensada and IFIMAC, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain;2. Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia), Cantoblanco, 28049 Madrid, Spain |
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Abstract: | The non-catalytic part of proteases frequently harbours domains responsible for regulation or targeting. Here, we describe a novel sequence motif conserved in proteins that belong to different protease superfamilies, the subtilases and Zn-containing metalloproteases. The structure of the transferrin receptor, a catalytically inactive member of the latter family, suggests that the protease-associated domain forms a lid structure that covers the active site. In addition to proteases, the domain is also found in two different families of plant vacuolar sorting receptors. |
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