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Microwave-assisted Solid Phase Peptide Synthesis on High Loaded Resins |
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| Authors: | Stéphanie Coantic Gilles Subra Jean Martinez |
| Institution: | 1.Institut de Chimie Séparative de Marcoule, UMR CNRS 5257, CEA Valrh?/DRCP/SCPS/LCAM,Bagnols sur Ceze Cedex,France;2.Faculté de Pharmacie de Montpellier,Institut des Biomolécules Max Mousseron UMR CNRS 5247, Universités Montpellier I et II,Montpellier,France |
| Abstract: | Kinetic of diffusion of reactants from the solution into the resin beads is a key factor of the efficiency of reaction in solid phase synthesis. We demonstrated in this paper that stirring is required to obtain homogeneous solution during the short coupling steps in microwave-assisted SPPS. Different types of resin, loading rate and coupling reactants were investigated to highlight this observation. |
| Keywords: | SPPS Microwave-assisted peptide synthesis Resin beads Mechanical stirring |
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