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Current and new insights on phytosterol oxides in plant sterol-enriched food
Authors:García-Llatas Guadalupe  Rodríguez-Estrada María Teresa
Institution:aNutrition and Food Chemistry Area, Faculty of Pharmacy, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain;bDipartimento di Scienze degli Alimenti, Università di Bologna, Viale G. Fanin, 40, 40127 Bologna, Italy
Abstract:Over the past 15 years, plant sterol-enriched foods have faced a great increase in the market, due to the asserted cholesterol-lowering effect of plant sterols. However, owing to their chemical structures, plant sterols can oxidize and produce a wide variety of oxidation products with controversial biological effects. Although oxyphytosterols can derive from dietary sources and endogenous formation, their single contribution should be better defined. The following review provides an overall and critical picture on the current knowledge and future perspectives of plant sterols-enriched food, particularly focused on occurrence of plant sterol oxidation products and their biological effects. The final objective of this overview is to evince the different aspects of plant sterols-enriched food that require further research, for a better understanding of the influence of plant sterols and their oxides on consumers’ health.
Keywords:Abbreviations: ACAT  acyl-coenzyme A cholesterol acyltransferase  ABC  adenosine triphosphate-binding cassette  CHD  coronary heart disease  COP  cholesterol oxidation products  CTO  crude tall-oil  CVD  cardiovascular disease  DOD  deodorizer distillate  EFSA  European Food Safety Authority  EC  European Commission  FDA  Food and Drug Administration  GC-FID  gas chromatography-flame ionization detector  GC&ndash  MS  gas chromatography&ndash  mass spectrometry  GRAS  generally recognized as safe  HDL  high density lipoproteins  LDL  low density lipoproteins  LXR  liver X receptor  NOAEL  no-observed-adverse-effect level  NPC1L1  Niemann-Pick C1-like protein  PE  phytosterol-esters  PLM  post-launch monitoring  PMM  post-market monitoring  POP  plant sterol oxidation products  PS  plant sterols  SIM  selected ion monitoring  SOP  sterol oxidation products  TBARs  thiobarbituric acid reactive substances  TLC&ndash  GC  thin-layer chromatography&ndash  gas chromatography  VLDL  very low density lipoproteins
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