Gangliosides and the multiscale modulation of membrane structure |
| |
Authors: | Cantù Laura Del Favero Elena Sonnino Sandro Prinetti Alessandro |
| |
Affiliation: | Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Italy |
| |
Abstract: | Cellular membranes are highly organized structures with multiple and multi-dimensional levels of order where lipid components are active players. The lipid role is especially evident in rafts, where lipid-driven collective interaction dictates the local structure of a membrane. However, lipids play as well other roles in many aspects of membrane mechanics and function.In this review, we would like to re-focus the attention of the readers on the importance of gangliosides in organizing the fine structure of cellular membranes, in lateral and transverse directions. Important biological events are likely to be affected such as the dynamic control of the shape of specialized plasma membrane areas and of the intracellular organelles, the in- and outward budding and fusion of membrane vesicles, the physical and functional coupling of the outer and the inner plasma membrane leaflet, involved in the transduction of signals across the membrane. |
| |
Keywords: | Abbreviations: Aβ amyloid β peptide: Ganglioside and glycosphingolipid nomenclature is in accordance with Svennerholm (Svennerholm 1980) and the IUPAC-IUBMB recommendations (IUPAC-IUBMB 1998) |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|