Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities |
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| Authors: | Zhou Xuefeng Lu Yanan Lin Xiuping Yang Bin Yang Xianwen Liu Yonghong |
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| Affiliation: | aKey Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;bKey and Open Laboratory of Marine and Estuarine Fisheries Resources and Ecology, Ministry of Agriculture, East China Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Shanghai 200090, China |
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| Abstract: | Four brominated aliphatic hydrocarbons (1–4), including a novel brominated ene-tetrahydrofuran named as mutafuran H (1), and five sterols (5–9) were isolated from the South China Sea sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of NMR (1H, 13C NMR, HSQC, HMBC, 1H–1H COSY, and NOESY), MS, and optical rotation analysis. Known compounds were identified by comparison of their NMR data with those reported in the literature. Compounds 1–4, and 6–9 were evaluated for their toxicity against Artemia salina larvae, and anti-acetylcholinesterase activity. |
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| Keywords: | Abbreviations: BSL, brine shrimp lethality AChE, acetylcholinesterase X., testudinariaXestospongia testudinaria PE, petroleum ether BPFC, brominated polyunsaturated fatty acids |
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