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Analysis on conservation of disulphide bonds and their structural features in homologous protein domain families |
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| Authors: | Ratna R Thangudu Malini Manoharan N Srinivasan Frédéric Cadet R Sowdhamini Bernard Offmann |
| Affiliation: | 1.Laboratoire de Biochimie et Génétique Moléculaire,Université de La Réunion,La Réunion,France;2.National Centre for Biological Sciences,GKVK Campus,Bangalore,India;3.Molecular Biophysics Unit,Indian Institute of Science,Bangalore,India;4.National Center for Biotechnology Information,U.S. National Library of Medicine,Bethesda,USA |
| Abstract: | BackgroundDisulphide bridges are well known to play key roles in stability, folding and functions of proteins. Introduction or deletion of disulphides by site-directed mutagenesis have produced varying effects on stability and folding depending upon the protein and location of disulphide in the 3-D structure. Given the lack of complete understanding it is worthwhile to learn from an analysis of extent of conservation of disulphides in homologous proteins. We have also addressed the question of what structural interactions replaces a disulphide in a homologue in another homologue. |
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