Effects of novel maleimide derivatives on cell cultures with different properties |
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| Authors: | Galyna Ostrovska Olga Maslova Delian Delev Radka Opatrilova Peter Kuzliak Nataliia Savytska |
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| Affiliation: | 1.Taras Shevchenko National University of Kyiv,Kiev,Ukraine;2.Hemafund Ltd.,Kiev,Ukraine;3.Department Pharmacology and Clinical Pharmacology, Medical Faculty,Medical University of Plovdiv,Plovdiv,Bulgaria;4.Department of Chemical Drugs, Faculty of Pharmacy,University of Veterinary and Pharmaceutical Sciences,Brno,Czech Republic;5.Laboratory of Structural Biology and Proteomics, Faculty of Pharmacy,University of Veterinary and Pharmaceutical Sciences,Brno,Czech Republic |
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| Abstract: | The paper is focused on pilot study of effects of novel synthetic protein kinase inhibitors—maleimide derivatives in different concentrations on normal, transformed and multipotent cell lines. Influence on cell proliferation and morphological characteristics has been demonstrated. The chosen agents cause antiproliferative effect on transformed cells and are not cytotoxic to normal cell lines. Moreover, different maleimide derivatives’ effects on multipotent cells in attached and floating states has been shown. Described results can be used for further research of the maleimide derivatives as antitumor agents. |
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