Telocytes of the human adult trigeminal ganglion |
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| Authors: | Mugurel Constantin Rusu Dragos Cretoiu Alexandra Diana Vrapciu Sorin Hostiuc Dan Dermengiu Vasile Sorin Manoiu Sanda Maria Cretoiu Nicolae Mirancea |
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| Institution: | 1.Division of Anatomy, Faculty of Dental Medicine,Carol Davila University of Medicine and Pharmacy,Bucharest,Romania;2.International Society of Regenerative Medicine and Surgery (ISRMS),Bucharest,Romania;3.MEDCENTER – Center of Excellence in Laboratory Medicine and Pathology,Bucharest,Romania;4.Division of Cellular and Molecular Biology and Histology, Department 2 Morphological Sciences, Faculty of Medicine,Carol Davila University of Medicine and Pharmacy,Bucharest,Romania;5.Victor Babes National Institute of Pathology,Bucharest,Romania;6.Division of Legal Medicine and Bioethics, Department 2 Morphological Sciences, Faculty of Medicine,Carol Davila University of Medicine and Pharmacy,Bucharest,Romania;7.Department of Forensic Pathology, National Institute of Legal Medicine,Bucharest,Romania;8.Department of Cellular and Molecular Biology,National Institute of Research and Development for Biological Sciences,Bucharest,Romania;9.Institute of Biology of Bucharest,The Romanian Academy,Bucharest,Romania |
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| Abstract: | Telocytes (TCs) are typically defined as cells with telopodes by their ultrastructural features. Their presence was reported in various organs, however little is known about their presence in human trigeminal ganglion. To address this issue, samples of trigeminal ganglia were tested by immunocytochemistry for CD34 and examined by transmission electron microscopy (TEM). We found that TCs are CD34 positive and form networks within the ganglion in close vicinity to microvessels and nerve fibers around the neuronal–glial units (NGUs). TEM examination confirmed the existence of spindle-shaped and bipolar TCs with one or two telopodes measuring between 15 to 53 μm. We propose that TCs are cells with stemness capacity which might contribute in regeneration and repair processes by: modulation of the stem cell activity or by acting as progenitors of other cells present in the normal tissue. In addition, further studies are needed to establish if they might influence the neuronal circuits. |
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