Absence of catch-down growth in Russell-Silver syndrome after short-term growth hormone treatment |
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Authors: | Azcona C Stanhope R |
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Institution: | Department of Endocrinology, Great Ormond Street Hospital for Children, London, UK.c.azcona@ich.ucl.ac.uk |
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Abstract: | We describe 3 children with Russell-Silver syndrome without growth hormone insufficiency who were treated with growth hormone for 2, 3. 7 and 6 years, showing a rapid growth acceleration. After cessation of growth hormone treatment, they grew at a normal rate without 'catch-down' growth. It may be possible that short intra-uterine growth retardation (IUGR) children with dysmorphic features respond to growth hormone therapy differently from non-dysmorphic IUGR short children. Short-term growth hormone treatment for children with Russell-Silver syndrome may avoid side effects and diminish costs. |
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