New methods for the synthesis of N-benzoylated uridine and thymidine derivatives; a convenient method for N-debenzoylation |
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Authors: | Maguire Anita R Hladezuk Isabelle Ford Alan |
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Affiliation: | Department of Chemistry, University College Cork, Cork, Ireland. a.r.maguire@ucc.ie |
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Abstract: | An improved procedure for the synthesis of N-benzoyl-2',3'-O-isopropylidene uridine via one-step selective N-benzoylation of 2',3' -O-isopropylidene uridine has been developed. An efficient synthetic route to N-benzoyl thymidine via initial tribenzoylation, followed by selective hydrolysis of the benzoates is also described. De-N-benzoylation of N-benzoylated thymidine and uridine derivatives can be conveniently effected under neutral conditions, by heating with benzyl alcohol. |
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Keywords: | Selective protection and deprotection N-Benzoyl uridine and thymidine |
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