Mechanisms of growth cone guidance and motility in the developing grasshopper embryo |
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Authors: | Isbister C M O'Connor T P |
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Affiliation: | Program in Neuroscience, Department of Anatomy, University of British Columbia, 2177 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada. |
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Abstract: | During neuronal pathfinding in vivo, growth cones must reorient their direction of migration in response to extracellular guidance cues. The developing grasshopper limb bud has proved to be a model system in which to examine mechanisms of growth cone guidance and motility in vivo. In this review we examine the contributions of adhesion and multiple guidance cues (semaphorins 1 and 2) in directing a growth cone steering event. Recent observations have suggested that the tibial pioneer growth cones are not directed via mechanisms of differential adhesivity. We present a model of growth cone steering that suggests a combination of adhesive and guidance receptors are important for a correct steering event and that guidance molecules may be important regulators of adhesive interactions with the actin cytoskeleton. |
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