<Emphasis Type="Italic">In vitro</Emphasis> gene regulatory networks predict <Emphasis Type="Italic">in vivo</Emphasis> function of liver |
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| Authors: | Youping Deng David R Johnson Xin Guan Choo Y Ang Junmei Ai Edward J Perkins |
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| Institution: | 1.Rush University Cancer Center, Rush University Medical Center,Chicago,USA;2.US Army Engineer Research and Development Center,Vicksburg,USA;3.SpecPro Inc.,Vicksburg,USA;4.School of Computing, University of Southern Mississippi,Hattiesburg,USA |
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| Abstract: | Background Evolution of toxicity testing is predicated upon using in vitro cell based systems to rapidly screen and predict how a chemical might cause toxicity to an organ in vivo. However, the degree to which we can extend in vitro results to in vivo activity and possible mechanisms of action remains to be fully addressed. |
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