Photoprotective effects of some quinoxaline 1,4-dioxides in hairless mice |
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Authors: | Hala U Gali-Muhtasib Makhluf J Haddadin Musa Z Nazer Nicole M Sodir and Samar W Maalouf |
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Institution: | (1) Department of Biology, American University of Beirut, Beirut, Lebanon;(2) Department of Chemistry, American University of Beirut, Beirut, Lebanon;(3) Present address: University of Jordan, Amman, Jordan |
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Abstract: | 2-benzoyl-3-phenylquinoxaline 1,4-dioxide (BPQ) and other substituted quinoxaline 1,4-dioxides (QdO) were tested for their
ability to inhibit the stimulations of ornithine decarboxylase (ODC) enzyme activity and DNA synthesis, two biochemical markers
linked to skin tumour promotion by ultraviolet B (UVB) radiation. Topical application of BPQ on the dorsal skin of hairless
mice was found to inhibit in a dose-dependent manner UVB-induced ODC activity and DNA synthesis. When applied 20 min before
UVB radiation, a dose of 17 mg BPQ applied in 0.4 ml of vehicle inhibited UVB-induced ODC activity and DNA synthesis by 95%
and 85%, respectively. This inhibitory effect is dependent on the time of administration of BPQ relative to UVB radiation,
with a generally greater inhibition observed when this compound is applied before rather than after UVB treatment. The inhibitory
abilities of the other QdO on the ODC and DNA responses induced by UVB radiation greatly varied and appear to be dependent
on the structure of the compounds and their metabolic activation in the skin following irradiation. The remarkable effectiveness
of BPQ against the ODC and DNA markers of UVB promotion is also observed following multiple applications of this agent. These
results suggest that QdO, in particular BPQ and certain derivatives of it, may be useful in protecting the skin against UVB-induced
skin damage. |
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Keywords: | UVB radiation DNA synthesis ODC activity photocarcinogenesis quinoxaline 1 4-dioxide mouse skin |
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