首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Structure of dengue virus: implications for flavivirus organization, maturation, and fusion
Authors:Kuhn Richard J  Zhang Wei  Rossmann Michael G  Pletnev Sergei V  Corver Jeroen  Lenches Edith  Jones Christopher T  Mukhopadhyay Suchetana  Chipman Paul R  Strauss Ellen G  Baker Timothy S  Strauss James H
Institution:Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. rjkuhn@bragg.bio.purdue.edu
Abstract:The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号