老年高血压合并2型糖尿病患者血清同型半胱氨酸、血尿酸水平变化及临床意义

目的：探讨老年高血压合并2型糖尿病患者血清同型半胱氨酸（Homocysteine,Hcy）、血尿酸（Serum uric acid,SUA）水平变化及其临床意义。方法：2012年9月至2013年9月期间,我院诊治的40例单纯高血压和40例高血压合并2型糖尿病患者,分别作为对照组和研究组,检测两组血清Hcy、SUA水平。结果：两组患者收缩压、舒张压比较无统计学差异（P〉0.05）。研究组空腹血糖、餐后2h血糖、血清Hcy、SUA均显著高于对照组（P〈0.05）。研究组中血管并发症患者血清Hcy、SUA为（25.0±5.0）μmol/L和（390.0±65.0）mmol/L显著高于无血管并发症患者（17.0±4.0）μmol/L和（330.0±55.0）mmol/L,血管并发症患者FBG、餐后2h血糖与无血管并发症患者比较无统计学差异（P〉0.05）。结论：高血压合并2型糖尿病患者血清Hcy、SUA异常升高,且存在慢性血管并发症患者两者水平更高,血清Hcy、SUA是老年高血压合并2型糖尿病的危险因素。

The Levels Change and Clinical Significance Research of Serum Homocysteine and Uric Acid for Old Patients with Hypertension and Type 2 Diabetes

Objective： To study the levels change and relationship of serum homocysteine （Hcy） and uric acid （UA） for old patients with hypertension and type 2 diabetes. Methods： The 40 patients with hypertension and 40 patients with hypertension and type 2 diabetes in our hospital during the period from Sep 2012 to Sep 2013 were regarded as the subjects of the control group and the study group. The levels of serum homocysteine and uric acid in the two groups and the relationship were measured and compared. Results： The systolic blood pressure, diastolic blood pressure of two groups was not statistically significant （P〉0.05）. In study group, fasting blood glucose, 2h postprandial blood glucose, serum Hcy, SUA were significantly higher than those in the control group （P〈0.05）. To observe the vascular complications in patients serum Hey, SUA were （25.0± 5.0）μmol/L and （390.0± 65.0）mmol/L significantly higher than that （ 17.0± 4.0）μmol/L and（330.0± 55.0）mmol/L of patients without vascular complications, there were no statistical differences in 2h glucose, FBG postprandial vascular complications in patients with and without vascular complications in patients with （P〉0.05）. Conclusion： The serum homocysteine and uric acid are the risk factors for old patients with hypertension and type 2 diabetes.