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A new convenient transformation of erythromycin A into clarithromycin |
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| Authors: | Allevi P Longo A Anastasia M |
| Affiliation: | Dipartimento di Chimica e Biochimica Medica, University of Milan, Via Saldini 50, I-20133, Milan, Italy |
| Abstract: | Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2′,4′′-hydroxy groups, methylation of the resulting 2′,4′′-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities. |
| Keywords: | Antibiotics antibacterials clarithromycin erythromycin A methylation |
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